publication . Article . 2011

The RTS,S vaccine candidate for malaria.

Jason A. Regules; James F. Cummings; Christian F. Ockenhouse;
Open Access
  • Published: 23 May 2011
Malaria continues to be a worldwide leading cause of morbidity and mortality, and the development of an effective malaria vaccine remains a research imperative. Of the multiple approaches that have been pursued, the RTS,S/AS01 vaccine candidate represents the most developed and clinically validated malaria vaccine formulation. Throughout its development, increasingly more effective adjuvants have been key in improving the potency of the vaccine. RTS,S-based vaccine formulations have been demonstrated to be safe, well tolerated, immunogenic, and to confer partial efficacy in both malaria-naive and -experienced adults as well as children. Further research to optim...
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Medical Subject Headings: parasitic diseases
free text keywords: Drug Discovery, Pharmacology, Molecular Medicine, Immunology, Adjuvant, medicine.medical_treatment, medicine, Malaria, medicine.disease, business.industry, business, Potency, Prime boost, Malaria epidemiology, Vaccine efficacy, Malaria vaccine, Immunology, RTS,S
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