publication . Article . 2015

A NOVEL GENETIC MARKER FOR INHERITED DISORDER OF THE HEART CONDUCTION SYSTEM

S. Yu. Nikulina; A. A. Chernova; S. S. Tretyakova;
Open Access Russian
  • Published: 01 Oct 2015 Journal: Российский кардиологический журнал, issue 10, pages 30-34 (issn: 1560-4071, eissn: 2618-7620, Copyright policy)
  • Publisher: «FIRMA «SILICEA» LLC 
Abstract
Aim. To study relation of mononucleotide polymorphism G>A of the gene SCN10A and development of inherited pathology of the heart conduction system.Material and methods. Totally, 260 persons investigated with primary disorders of cardiac conduction (71 patient with atrioventricular conduction disorder, 84 patients with the Right His bundle branch conduction disorder and 105 — the Left) and 263 persons without any found cardiovascular diseases (controls). All patients underwent standard cardiological investigation, retrospective analysis of previous investigation data (if available), molecular genetic test of DNA.Results. The obtained results showed statistical...
Subjects
free text keywords: sodium channels gene, heart conduction disorders, lcsh:Diseases of the circulatory (Cardiovascular) system, lcsh:RC666-701
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