Glomerulonephritis is also known as glomerular nephritis (GN) or glomerular disease. It is a disease of the kidney, characterized by inflammation of the glomeruli. The present study was undertaken with the objectives to explore the incidence and clinical profile of non diabetic renal disease in type 2 Diabetes Mellitus, to observe renal histology, to identify nature of glomerular disease, to identify the Prognostic factors and to observe the response to specific treatment. The Present study was conducted in June 1, 2001 to Dec 31, 2004 at Medical College Thiruvananthapuram. Twenty four patients with mean age of 51 were included in the study. Male and female ratio is 13:11. Mean duration of the patients suffering with diabetes mellitus is 8 years. Mean duration of the patients suffering with hypertension is 5 years. All patients had non nephrotic range proteinuria with a maximum of 2.8gms. Total number of patients are divided into five groups. We have observed thirteen patients with diabetes mellitus and glomerular disease with or without tubulo inerstitial nephritis. Five patients with diabetes mellitus and glomerular disease only. Four patients with diabetes mellitus only. One patient with diabetes mellitus with tubulo inerstitial nephritis. One patient with glomerular disease and tubulo inerstitial nephritis. Eleven patients were died. In the present study the relation between the variables is not statistically significant. Hence we suggest to carry out the study further with higher sample size to explore the relation well.