publication . Other literature type . Article . 2017

Acute Poisoning with Methadone (Dolphin) (Review)

Georgy A. Livanov; Alexander T. Loladze; Bair V. Batotsyrenov; Alexey N. Lodyagin; Sergey I. Glushkov; Tatiana V. Kharitonova; Alexandra A. Ivanova; Dmitry V. Baranov; Anna M. Antonova;
Open Access
  • Published: 01 Jun 2017
  • Publisher: FSBI SRIGR RAMS
Abstract
Most publications report on the use of methadone as a medication, however an increase of the illegal use of methadone has been demonstrated worldwide over the recent years, thus increasing the number of hospitalizations due to acute poisoning with this synthetic opioid. The aim of the present review was to summarize current data on the mechanisms of toxicity, selective toxicity, toxicokinetics and toxicodynamics of methadone (Dolphin). The involvement of CNS, respiratory, cardiovascular and urinary systems in acute poisoning with methadone was dis- cussed. The practice of use of methadone in many countries as a medicine for the replacement therapy for opiate add...
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free text keywords: acute poisoning, opioids, methadone, heroin, hypoxia, naloxone, antihypoxant, cytoflavin, Opiate, Toxicity, Anesthesia, Addiction, media_common.quotation_subject, media_common, Opioid, medicine.drug, medicine, Acute toxicity, Intensive care medicine, medicine.medical_specialty, Methadone, Heroin, business.industry, business, Antidote, medicine.medical_treatment, lcsh:Medical emergencies. Critical care. Intensive care. First aid, lcsh:RC86-88.9
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