Ppp2ca knockout in mice spermatogenesis
Copyright policy )Ppp2ca knockout in mice spermatogenesis
Protein phosphatase 2A (PP2A) is a ubiquitous serine/threonine phosphatase involved in meiosis, mitosis, sperm capacitation, and apoptosis. Abberant activity of PP2A has been associated with a number of diseases. The homolog PPP2CA and PPP2CB can each function as the phosphatase catalytic subunit generally referred to as PP2AC. We generated a Ppp2ca conditional knockout (CKO) in C57BL/6J mice. Exon 2 of Ppp2ca was knocked out in a spatial or temporal-specific manner in primordial germ cells at E12.5. This Ppp2ca-null mutation caused infertility in male C57BL/6J mice. These CKO mice provide a powerful tool to study the mechanisms of Ppp2ca in development and disease.
- Nanjing Medical University China (People's Republic of)
Male, Mice, Knockout, Integrases, Reverse Transcriptase Polymerase Chain Reaction, Blotting, Western, Real-Time Polymerase Chain Reaction, Mice, Inbred C57BL, Meiosis, Mice, Animals, Protein Phosphatase 2, RNA, Messenger, Spermatogenesis, Cells, Cultured, Infertility, Male
Male, Mice, Knockout, Integrases, Reverse Transcriptase Polymerase Chain Reaction, Blotting, Western, Real-Time Polymerase Chain Reaction, Mice, Inbred C57BL, Meiosis, Mice, Animals, Protein Phosphatase 2, RNA, Messenger, Spermatogenesis, Cells, Cultured, Infertility, Male
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