Plasma concentrations of 1-deamino-8-d-arginine vasopressin after intragastric administration in the rat

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 1985Publisher:Oxford University Press (OUP)Journal:Acta Endocrinologica, volume 108, pages 179-183 (issn: 0804-4643, eissn: 1479-683X,

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Authors: S, Lundin; P, Melin; H, Vilhardt;

doi: 10.1530/acta.0.1080179

pmid: 3969814

Plasma concentrations of 1-deamino-8-d-arginine vasopressin after intragastric administration in the rat

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Abstract

Abstract. A sensitive and specific radioimmunoassay for 1-deamino-8-d-arginine vasopressin (DDAVP) was developed. Plasma concentrations of DDAVP after intragastric administration were determined in non-fasted rats and a dose-related increase in plasma levels was obtained. The immunoidentity of plasma DDAVP and standard was established by high performance liquid chromatography (HPLC). Correlation of biological and immunological responses of DDAVP was assessed using the antidiuretic effect in the Brattleboro (diabetes insipidus) rat.

Related Organizations

University of Copenhagen
Denmark
Lund University
Sweden

Keywords

Stomach, Radioimmunoassay, Rats, Brattleboro, Rats, Inbred Strains, Cross Reactions, Rats, Arginine Vasopressin, Animals, Deamino Arginine Vasopressin, Female, Chromatography, High Pressure Liquid

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