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Plasma concentrations of 1-deamino-8-d-arginine vasopressin after intragastric administration in the rat

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 1985Publisher:Oxford University Press (OUP)Journal:Acta Endocrinologica, volume 108, pages 179-183 (issn: 0804-4643, eissn: 1479-683X,

Authors: Stefan Lundin; Per Melin; Hans Vilhardt;

doi: 10.1530/acta.0.1080179

pmid: 3969814

Plasma concentrations of 1-deamino-8-d-arginine vasopressin after intragastric administration in the rat

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Abstract

Abstract. A sensitive and specific radioimmunoassay for 1-deamino-8-d-arginine vasopressin (DDAVP) was developed. Plasma concentrations of DDAVP after intragastric administration were determined in non-fasted rats and a dose-related increase in plasma levels was obtained. The immunoidentity of plasma DDAVP and standard was established by high performance liquid chromatography (HPLC). Correlation of biological and immunological responses of DDAVP was assessed using the antidiuretic effect in the Brattleboro (diabetes insipidus) rat.

Related Organizations

Lund University
Sweden
University of Copenhagen
Denmark

Keywords

Stomach, Radioimmunoassay, Rats, Brattleboro, Rats, Inbred Strains, Cross Reactions, Rats, Arginine Vasopressin, Animals, Deamino Arginine Vasopressin, Female, Chromatography, High Pressure Liquid

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	54
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%