RIBONUCLEOPROTEIN PARTICLES CONTAINING mRNA and pre-mRNA

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 1973Publisher:Oxford University Press (OUP)Journal:Acta Endocrinologica, volume 74, pages S130-S167 (issn: 0804-4643, eissn: 1479-683X,

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Authors: O P, Samarina; E M, Lukanidin; G P, Georgiev;

doi: 10.1530/acta.0.074s130

pmid: 4204622

RIBONUCLEOPROTEIN PARTICLES CONTAINING mRNA and pre-mRNA

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Abstract

ABSTRACT This paper is a review of the data concerning the nature, structural organization, properties and biological significance of the particles, containing mRNA and pre-mRNA (precursor of mRNA), i. e., (1) nuclear pre-mRNA-containing particles (2) free cytoplasmic mRNP (ribonucleoproteins), or informosomes (3) polysome-bound mRNP. Some new data on the comparison of nuclear and cytoplasmic particles, the nature of poly A-containing structures, involvement of informofers in Adenovirusspecific RNA transfer are presented. The general scheme of mRNA transport from nucleus to cytoplasm is discussed.

Keywords

Cell Nucleus, Cytoplasm, Nucleic Acid Hybridization, Proteins, DNA, Iodine Radioisotopes, Mice, Microscopy, Electron, Polyribosomes, Protein Biosynthesis, DNA, Viral, Centrifugation, Density Gradient, Animals, Humans, Electrophoresis, Polyacrylamide Gel, Amino Acid Sequence, Carbon Radioisotopes, RNA, Messenger, Phosphorus Radioisotopes, Edetic Acid

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