Powered by OpenAIRE graph
Found an issue? Give us feedback
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Kemija u Industriji;...arrow_drop_down
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
Kemija u Industriji
Article
License: CC BY
Data sources: UnpayWall
versions View all 2 versions
addClaim

This Research product is the result of merged Research products in OpenAIRE.

You have already added 0 works in your ORCID record related to the merged Research product.
addClaim

This Research product is the result of merged Research products in OpenAIRE.

You have already added 0 works in your ORCID record related to the merged Research product.

Bioaktivne molekule – policiklički derivati gvanidina

Authors: Šekutor, Marina; Mlinarić-Majerski, Kata;

Bioaktivne molekule – policiklički derivati gvanidina

Abstract

Biološka aktivnost različitih adamantanskih derivata i njihova primjena opisane su u brojnim preglednim člancima. Isto tako, mnogi revijalni članci opisuju biološku aktivnost i primjenu gvanidinskih spojeva. Međutim, do sada nije načinjen pregled koji bi se bavio gvanidinskim derivatima adamantana i drugih policikla, tj. spojevima koji sadrže obje navedene podjedinice u istoj molekuli. U ovom radu bit će stoga dan pregled policikličkih derivata gvanidina, i to s naglaskom na njihovu primjenu kao potencijalnih farmakofora.

Country
Croatia
Related Organizations
Subjects by Vocabulary

Microsoft Academic Graph classification: Chemistry

Keywords

General Chemical Engineering, adamantan ; policikli ; gvanidin ; bioaktivni spojevi ; farmakofori, General Chemistry

61 references, page 1 of 7

1. a) W. J. Geldenhuys, S. F. Malan, J. R. Bloomquist, A. P. Marchand, C. J. Van der Schyf, Pharmacology and structure-activity relationships of bioactive polycyclic cage compounds: a focus on pentacycloundecane derivatives, Med. Res. Rev. 25 (2005) 21-48, doi: http://dx.doi.org/10.1002/med.20013. b) C. J. Van der Schyf, W. J. Geldenhuys, Polycyclic compounds: ideal drug scaffolds for the design of multiple mechanism drugs?, Neurotherapeutics 6 (2009) 175-186, doi: http:// dx.doi.org/10.1016/j.nurt.2008.10.037. c) J. Joubert, W. J. Geldenhuys, C. J. Van der Schyf, D. W. Oliver, H. G. Kruger, T. Govender, S. F. Malan, Polycyclic cage structures as lipophilic scaffolds for neuroactive drugs, ChemMedChem 7 (2012) 375-384, doi: http://dx.doi.org/10.1002/cmdc.201100559.

2. a) O. K. Onajole, P. Govender, P. D. van Helden, H. G. Kruger, G. E. Maguire, I. Wiid, T. Govender, Synthesis and evaluation of SQ109 analogues as potential anti-tuberculosis candidates, Eur. J. Med. Chem. 45 (2010) 2075-2079, doi: http://dx.doi. org/10.1016/j.ejmech.2010.01.046. b) G. Lamoureux, G. Artavia, Use of the adamantane structure in medicinal chemistry, Curr. Med. Chem. 17 (2010) 2967-2978, doi: http:// dx.doi.org/10.2174/092986710792065027. [OpenAIRE]

3. a) L. Wanka, K. Iqbal, P. R. Schreiner, The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives, Chem. Rev. 113 (2013) 3516-3604, doi: http://dx.doi. org/10.1021/cr100264t. b) J. Liu, D. Obando, V. Liao, T. Lifa, R. Codd, The many faces of the adamantyl group in drug design, Eur. J. Med. Chem. 46 (2011) 1949-1963, doi: http:// dx.doi.org/10.1016/j.ejmech.2011.01.047. [OpenAIRE]

4. R. C. Fort Jr., Adamantane - The chemistry of diamond molecules, Marcel Dekker, Inc., New York, 1976.

5. C. F. Chew, A. Guy, P. C. Biggin, Distribution and dynamics of adamantanes in a lipid bilayer, Biophys. J. 95 (2008) 5627- 5636, doi: http://dx.doi.org/10.1529/biophysj.108.139477. [OpenAIRE]

6. T. Ishikawa, Superbases for organic synthesis: guanidines, amidines and phosphazenes and related organocatalysts, John Wiley & Sons, Ltd, Chichester, West Sussex, United Kingdom, 2009., doi: http://dx.doi.org/10.1002/9780470740859.

7. E. D. Raczyńska, M. K. Cyrański, M. Gutowski, J. Rak, J.-F. Gal, P.-C. Maria, M. Darowska, K. Duczmal, Consequences of proton transfer in guanidine, J. Phys. Org. Chem. 16 (2003) 91-106, doi: http://dx.doi.org/10.1002/poc.578.

8. D. Castagnolo, S. Schenone, M. Botta, Guanylated diamines, triamines, and polyamines: Chemistry and biological properties, Chem. Rev. 111 (2011) 5247-5300, doi: http://dx.doi. org/10.1021/cr100423x. [OpenAIRE]

9.C. L. Hannon, E. V. Anslyn, The guanidinium group: Its biological role and synthetic analogs, Bioorganic Chemistry Frontiers, vol. 3, Springer, Berlin, 1993., str. 193-255.

10. R. G. S. Berlinck, Natural guanidine derivatives, Nat. Prod. Rep. 16 (1999) 339-365, doi: http://dx.doi.org/10.1039/ a900338j.

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    0
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
  • citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    0
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
    Powered byBIP!BIP!
Powered by OpenAIRE graph
Found an issue? Give us feedback
citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
moresidebar

Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.