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Nuchal translucency and lymphatic system maldevelopment

descriptionPublicationkeyboard_double_arrow_right Article 10 Jul 2009Embargo end date: 17 Jun 2017 Italy, Germany English Publisher:Walter de Gruyter GmbHJournal:jpme, volume 37, pages 673-676 (issn: 0300-5577, eissn: 1619-3997,

Authors: C. Bellini; M. Rutigliani; BOCCARDO, FRANCESCO; BONIOLI, EUGENIO; CAMPISI, CORRADINO; GRILLO, FEDERICA; T. Bellini; +2 Authors

doi: 10.1515/jpm.2009.107 , 10.18452/11399

pmid: 19591554

handle: 11567/308889

Nuchal translucency and lymphatic system maldevelopment

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Abstract

Abstract We describe the histological examination of 18 aborted fetuses that had increased nuchal translucency (NT) between 11+0 and 13+6 weeks' gestation. The aim of this study was to assess the corresponding NT anatomic features by immunohistochemical (IHC) investigation. A morphological study was performed using lymphatic and blood endothelial specific markers, as well as smooth muscle actin (SMA). We found that all 18 cases were D2-40 positive, CD31 positive, and CD34 negative, suggesting the presence of nuchal lymph vessel ectasia. We found that 12/18 cases were SMA staining positive and 6/18 cases were SMA negative, suggesting that 6/18 cases had nuchal cystic lymphangiectasia, whereas 12/18 had cystic hygromas. The present data seem to confirm the reasonable hypothesis that lymphangiogenesis plays a relevant role in nuchal edema, increased NT, and that increased NT is the result of a lymphatic malformation or a delayed development of the lymphatic system.

Countries

Italy, Germany

Related Organizations

Keywords

Lymphangiectasis, Antibodies, Monoclonal, CD31 antigen; CD34 antigen; podoplanin; smooth muscle actin; cystic lymphangioma; immunohistochemistry; lymphangiectasis; lymphangiogenesis; lymphatic system; Down Syndrome, Antigens, CD34, Immunohistochemistry, Actins, Cohort Studies, Lymphatic System, Platelet Endothelial Cell Adhesion Molecule-1, Antibodies, Monoclonal, Murine-Derived, Pregnancy, Aborted Fetus, Humans, Female, Lymphangioma, Cystic, Down Syndrome, Lymphangiogenesis, Nuchal Translucency Measurement, Retrospective Studies

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	18
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%