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Serbian Journal of Experimental and Clinical Research
Article . 2017 . Peer-reviewed
License: CC BY NC ND
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antiproliferative activity of gold iii complexes with esters of cyclohexyl functionalized ethylenediamine n n diacetate

Authors: Pantelić, Nebojša; Stanojković, Tatjana P.; Zmejkovski, Bojana B.; Kaluđerović, Goran N.; Sabo, Tibor J.;

antiproliferative activity of gold iii complexes with esters of cyclohexyl functionalized ethylenediamine n n diacetate

Abstract

AbstractSix gold(III) complexes with esters of cyclohexyl-functionalized ethylenediamine-N,N’-diacetate, general formula [AuCl2{(S,S)-R2eddch}]PF6, [(S,S)-eddch = (S,S)-ethylenediamine-N,N’-di-2-(3-cyclohexyl)propanoate, R = Me, Et,n-Pr,n-Bu,i-Bu,i-Am,1–6, respectively], were tested against cancer cell lines such as human melanoma Fem-x, human colon carcinoma LS174T and non-small cell lung carcinoma A549 as well as a non-cancerous human embryonic lung fibroblasts MRC-5 using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay with the aim of assessingin vitroantitumoral activity and selectivity. All investigated complexes showed lower cytotoxicity and better or similar selectivity in comparison to cisplatin, used as reference compound. Complex [AuCl2{(S,S)-(i-Am)2eddch}]PF6(6) demonstrated the highest activity against Fem-x (IC50= 14.98 ± 0.34 μM). Additionally, the same complex expressed 4.5 times higher selectivity than cisplatin.

Country
Serbia
Keywords

gold(iii) complexes, R2eddatip-liganada, R, selectivity, selektivnost, zlato(III) kompleksi, gold(III) complexes, Medicine, cytotoxicity, citotoksičnost, R2eddatype-ligands, r2edda type-ligands

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  • citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    2
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
2
Average
Average
Average
Green
gold