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Publication . Article . 2003

Structure and Function of Natural-Killer-Cell Receptors

Sun, Peter D.;
Open Access  
Published: 01 Feb 2003
Publisher: Springer Science and Business Media LLC
The function of natural-killer (NK) cells is modulated by the balance between a number of activating and inhibitory receptors. Killer immunoglobulinlike receptors (KIRs) are mostly inhibitory receptors. They play a critical role in recognizing self-class-I major histocompatibility complex (MHC) molecules and thus protect healthy host cells from NK-targeted lysis. In contrast, both NKG2D and CD16 are activating NK receptors that trigger the NK-cell lysis of various tumor and virally infected cells through either direct ligand engagement or antibody-dependent cellular cytotoxicity (ADCC). Through structural studies of members of these distinct receptor families, in particular, the structure and recognition between KIR2DL2 and HLA-Cw3, that between NKG2D and ULBP3, and that between CD16 and IgG Fc, considerable understandings have been achieved about their function and their ligand recognition.
Subjects by Vocabulary

Microsoft Academic Graph classification: Natural killer cell medicine.anatomical_structure medicine CD16 NKG2D Major histocompatibility complex biology.protein biology Antibody-dependent cell-mediated cytotoxicity Immune receptor Receptor Cell biology Lymphokine-activated killer cell

Medical Subject Headings: chemical and pharmacologic phenomena hemic and immune systems



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Immunologic Research
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