descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 1992 English Publisher:Elsevier BVJournal:Chest, volume 102, pages 189-194 (issn: 0012-3692,

Authors: Vassiliki Filaditaki; Nikolaos Tzanakis; Vassiliki Salesiotou; Demosthenes Bouros; Nikolaos M. Siafakas; Nikolaos Thalassinos;

doi: 10.1378/chest.102.1.189

pmid: 1623751

Respiratory Muscle Strength in Hypothyroidism

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Abstract

To investigate respiratory muscle strength in patients with hypothyroidism, global respiratory muscle strength was assessed by measuring mouth pressure during PImax and PEmax efforts. Maximum pressures, VC, FEV1, FVC, T3, T4, and TSH were measured in 43 hypothyroid patients. Measurements were made before and three months after replacement therapy with thyroxine. The results showed that the mean value of PImax and PEmax increased after treatment. Significant change was found in the mean value of VC, FEV1, and FVC after treatment but not in the FEV1/FVC ratio. A highly statistically significant linear relationship was found between PImax and TSH and between PEmax and TSH as well as between PImax and T3 and PEmax and T3. We conclude that hypothyroidism affects respiratory muscle strength and that this weakness is linearly related to thyroid hormone levels. Respiratory muscle weakness is present in both inspiratory and expiratory muscles and is reversible with treatment.

Related Organizations

University of Crete
Greece
Evangelismos Hospital
Greece

Keywords

Adult, Male, Respiration, Total Lung Capacity, Thyrotropin, Middle Aged, Respiratory Muscles, Thyroxine, Hypothyroidism, Forced Expiratory Volume, Myxedema, Pressure, Humans, Triiodothyronine, Female, Aged

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