Nitazoxanide is active against Mycobacterium leprae
Copyright policy )Nitazoxanide is active against Mycobacterium leprae
Nitazoxanide (NTZ) is an anti-parasitic drug that also has activity against bacteria, including Mycobacterium tuberculosis. Our data using both radiorespirometry and live-dead staining in vitro demonstrate that NTZ similarly has bactericidal against M. leprae. Further, gavage of M. leprae-infected mice with NTZ at 25mg/kg provided anti-mycobacterial activity equivalent to rifampicin (RIF) at 10 mg/kg. This suggests that NTZ could be considered for leprosy treatment.
- Health Resources and Services Administration United States
- Austin Health & Human Services Department United States
- Infectious Disease Research Institute United States
Science, Q, R, Microbial Sensitivity Tests, Nitro Compounds, Anti-Bacterial Agents, Mycobacterium leprae, Mice, Thiazoles, Leprosy, Medicine, Animals, Research Article
Science, Q, R, Microbial Sensitivity Tests, Nitro Compounds, Anti-Bacterial Agents, Mycobacterium leprae, Mice, Thiazoles, Leprosy, Medicine, Animals, Research Article
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).16 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!