Actions
  • shareshare
  • link
  • cite
  • add
add
auto_awesome_motion View all 18 versions
Publication . Article . Other literature type . 2013

Dietary BMAA Exposure in an Amyotrophic Lateral Sclerosis Cluster from Southern France.

Estelle Masseret; Sandra Banack; Farid Boumédiène; Eric Abadie; Luc Brient; Fabrice Pernet; Raoul Juntas-Morales; +5 Authors
Open Access
English
Published: 13 Dec 2013
Publisher: HAL CCSD
Country: France
Abstract

BackgroundDietary exposure to the cyanotoxin BMAA is suspected to be the cause of amyotrophic lateral sclerosis in the Western Pacific Islands. In Europe and North America, this toxin has been identified in the marine environment of amyotrophic lateral sclerosis clusters but, to date, only few dietary exposures have been described.ObjectivesWe aimed at identifying cluster(s) of amyotrophic lateral sclerosis in the Hérault district, a coastal district from Southern France, and to search, in the identified area(s), for the existence of a potential dietary source of BMAA.MethodsA spatio-temporal cluster analysis was performed in the district, considering all incident amyotrophic lateral sclerosis cases identified from 1994 to 2009 by our expert center. We investigated the cluster area with serial collections of oysters and mussels that were subsequently analyzed blind for BMAA concentrations.ResultsWe found one significant amyotrophic lateral sclerosis cluster (p = 0.0024), surrounding the Thau lagoon, the most important area of shellfish production and consumption along the French Mediterranean coast. BMAA was identified in mussels (1.8 µg/g to 6.0 µg/g) and oysters (0.6 µg/g to 1.6 µg/g). The highest concentrations of BMAA were measured during summer when the highest picocyanobacteria abundances were recorded.ConclusionsWhile it is not possible to ascertain a direct link between shellfish consumption and the existence of this ALS cluster, these results add new data to the potential association of BMAA with sporadic amyotrophic lateral sclerosis, one of the most severe neurodegenerative disorder.

Subjects by Vocabulary

Microsoft Academic Graph classification: Dietary exposure Bivalvia biology.organism_classification biology Microbial toxins Cyanotoxin Shellfish Ecology Amyotrophic lateral sclerosis medicine.disease medicine Zoology

Subjects

Amyotrophic lateral sclerosis, BMAA, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Research Article, Multidisciplinary, Medicine, R, Science, Q

Related to Research communities
Heritage Science
Download fromView all 6 sources
lock_open
PLoS ONE
Article
License: cc-by
Providers: UnpayWall
moresidebar