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Polycomb Group Genes: Keeping Stem Cell Activity in Balance

descriptionPublicationkeyboard_double_arrow_right Article 29 Apr 2008 English Publisher:Public Library of Science (PLoS)Journal:PLoS Biology, volume 6, page e113 (eissn: 1545-7885, Copyright policy )Funded by:CIHR | unidentified
Authors: Martin Sauvageau; Guy Sauvageau;

doi: 10.1371/journal.pbio.0060113

pmid: 18447587

pmc: PMC2689701

Polycomb Group Genes: Keeping Stem Cell Activity in Balance

Abstract

Overexpression of Polycomb group genes is often associated with cancer development, whereas complete deletion results in loss of stem cell activity. New studies show that partial loss of function of Polycomb group genes enhances the activity of blood stem/progenitor cells.

Related Organizations
Keywords

Repressor Proteins, QH301-705.5, Stem Cells, Animals, Humans, Polycomb-Group Proteins, Biology (General), Hematopoietic Stem Cells, Primer

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 43
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
43
Top 10%
Top 10%
Top 10%
Green
gold
Related to Research communities
Knowmad Institut
Cancer Research