The monograph presents the main methodological principles used in the practice of regulating economic entities with their global natural environment. The methods of management of companies, territorial economic entities in the specific conditions of global environmental changes, which are based on the principle of sustainable development, are characterized. The problem of forming a system of concepts used in research related to the problems of global ecology is raised. It is intended for specialists working in the field of economic problems of global ecology, practitioners engaged in problems of environmental economics, researchers, teachers, graduate students, students.