descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 1971 English Publisher:SAGE PublicationsJournal:Laboratory Animals, volume 5, pages 153-162 (issn: 0023-6772, eissn: 1758-1117,

Authors: Göran Magnusson; Carl-Henrik Ramsay;

doi: 10.1258/002367771781006500

pmid: 5126326

Urolithiasis in the rat

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Abstract

As incidental findings uroliths were observed in the renal pelvis of Sprague-Dawley rats in an 18-month toxicity study. Of 220 rats examined, uroliths were found in 55 (35 males and 20 females). Infrared spectral analysis of the stones indicated a content of ammonium magnesium phosphate. Formation of the uroliths may have started by mineralization of degenerating hyperplastic epithelium of the renal papilla.

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Keywords

Male, Hyperplasia, Nephritis, Age Factors, Rats, Inbred Strains, Kidney, Diet, Phosphates, Rats, Quaternary Ammonium Compounds, Rodent Diseases, Sex Factors, Animals, Female, Magnesium, Urinary Calculi

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