Diketene analogs as .BETA.-lactamase inhibitor.

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1989 English Publisher:Pharmaceutical Society of JapanJournal:Chemical and Pharmaceutical Bulletin, volume 37, pages 824-825 (issn: 0009-2363, eissn: 1347-5223,

Copyright policy )

Authors: K, Tanizawa; K, Santoh; Y, Kanaoka;

doi: 10.1248/cpb.37.824

pmid: 2787706

Diketene analogs as .BETA.-lactamase inhibitor.

- Summary
- Subjects
- Metrics

Abstract

Compounds having a structural analogy with diketene have been synthesized and their potencies as beta-lactamase inhibitors have been studied. Among six compounds so far tested, alpha-phenyl-beta-benzylidene-3-propanolide was shown to be an irreversible inhibitor of the enzyme. The availability of simple monocyclic compounds as beta-lactamase inhibitors is discussed.

Keywords

Chemistry, Lactones, Chemical Phenomena, beta-Lactamase Inhibitors

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	5
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average