AbstractSince 2020, the progress towards the achievement of Sustainable Development Goal (SDG) 2– Zero Hunger has faced a sudden stall due to an ongoing “polycrisis”. While some countries are on track, a great effort is still globally necessary to achieve the SDG2 targets. Here we provide a brief background about SDG2, including its synergies and trade-offs with other SDGs. We then identify and discuss the main challenges that the pathway towards zero hunger will have to tackle. The lack of a systemic approach, together with the complex, global, and nested dimensions of food systems are identified as key elements to be carefully considered when designing sustainability strategies. This means that a variety of stakeholders are called to simultaneously and cooperatively act on multiple fronts to ensure a safe, equal, and just progress of all countries and populations towards the achievement of SDG2.