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MicroRNA roles in beta-catenin pathway

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 21 Sep 2010 English Publisher:Springer Science and Business Media LLCJournal:Molecular Cancer, volume 9 (eissn: 1476-4598, Copyright policy )
Authors: Han Lei; Zhang Jun-Xia; Huang Kai; You Yong-Ping; Jiang Tao; Pu Pei-Yu; Kang Chun-Sheng;

doi: 10.1186/1476-4598-9-252

pmid: 20858269

pmc: PMC2955614

MicroRNA roles in beta-catenin pathway

Abstract

Abstractβ-catenin, a key factor in the Wnt signaling pathway, has essential functions in the regulation of cell growth and differentiation. Aberrant β-catenin signaling has been linked to various disease pathologies, including an important role in tumorigenesis. Here, we review the regulation of the Wnt signaling pathway as it relates to β-catenin signaling in tumorigenesis, with particular focus on the role of microRNAs. Finally, we discuss the potential of β-catenin targeted therapeutics for cancer treatment.

Related Organizations
Keywords

Cancer Research, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Review, Models, Biological, Wnt Proteins, MicroRNAs, Oncology, Neoplasms, Molecular Medicine, Animals, Humans, RC254-282, beta Catenin, Signal Transduction

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 110
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 1%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
110
Top 10%
Top 10%
Top 1%
Green
gold
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Knowmad Institut
Cancer Research