The trade of cultural products is a new industry arising from the big background of economic globalization; it is of strong permeability, wide cross-industry, and relatively intensive knowledge. It stands at the top of the commodity industry chain, is gradually recognized and cherished by people. Its development is also one of the obvious signs to measure the regional competitiveness. In view of the corresponding evaluation index of the sales route of cultural products in financial and trade activities participation, the study carries out the comprehensive weighting, and optimizes the results of the weighting based on the variation coefficient method. The importance between the subjective weight and objective weight is verified according to the instance data and the operating income margin of cultural products is predicted.