To the Editor: Kastrati et al recently reported1 significantly less restenosis with lesions randomized to deployment of one stent design (ACS RX Multi-Link, [ML]) than with a related design (Multi-Link RX Duet, [DT]) from the same manufacturer (Guidant). They attributed the difference in restenosis to the difference in strut thickness. Although the two stent designs do differ significantly in strut thickness, there are other differences in design and mechanical properties that might impact on restenosis. The DT has greater radial strength: when tested in vitro in a pressure chamber, the DTs collapsed at a higher pressure (1.81±0.01 atm) than the MLs (0.77±0.03 atm, P <0. 05) (unpublished observations). Some experimental data suggest that greater stent hoop strength may cause increased neoimtimal proliferation.2 The extent of metal coverage of vessel wall is greater for the ML …