Pilocarpine was infused into the conjunctival sac of glaucoma patients with the Sage Model 216 pump. Doses as high as 20 mg were given in 30 min without ocular or systemic toxicity. The ocular hypotension effect, in the same group of patients, was doubled over 4-percent pilocarpine drops given four times daily. In addition to increased efficacy the duration of the ocuoar hypotensive effect was markedly prolonged. Return of ocular pressure to baseline values after a single pump infusion of 20 mg required an average of 33.9 h.