publication . Article . 2007

Integrated profiling of basal and luminal breast cancers.

José Adélaïde; Pascal Finetti; Ismahane Bekhouche; Laetitia Repellini; Jeannine Geneix; Fabrice Sircoulomb; Emmanuelle Charafe-Jauffret; Nathalie Cervera; Jérôme Desplans; Daniel Parzy; ...
Open Access
  • Published: 15 Dec 2007
  • Country: Netherlands
Abstract
Basal and luminal are two molecular subtypes of breast cancer with opposite histoclinical features. We report a combined, high-resolution analysis of genome copy number and gene expression in primary basal and luminal breast cancers. First, we identified and compared genomic alterations in 45 basal and 48 luminal tumors by using 244K oligonucleotide array comparative genomic hybridization (aCGH). We found various genome gains and losses and rare high-level gene amplifications that may provide therapeutic targets. We show that gain of 10p is a new alteration in basal breast cancer and that a subregion of the 8p12 amplification is specific of luminal tumors. Rare ...
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free text keywords: Gene expression, Breast cancer, medicine.disease, medicine, ETV6, Biology, Pathology, medicine.medical_specialty, Cancer, Comparative genomic hybridization, Gene, Basal (phylogenetics), Cancer research, Insulin-like growth factor 1 receptor
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