In an attempt to relate nominal standard dose (NSD) to reactions and complications, the records of 516 patients who had received high dose radiotherapy for invasive squamous cell carcinoma of the uterine cervix were studied. There were two treatment plans: (a) Plan I: two applications of intracavitary radiation plus parametrial radiation; and (b) Plan II: external radiation to the midplane of the pelvis, followed with one intracavitary application. The ret dose calculated at the end of therapy revealed a significant statistical correlation between reactions and dosage in both plans, i.e., .0000029 and .033, respectively. At maximal recovery, however, no significant correlation was seen for patients in Plan I and only borderline significance for those in Plan II.