publication . Article . 2005

Orthologs, paralogs, and evolutionary genomics.

Eugene V. Koonin;
Open Access
  • Published: 30 Aug 2005
Orthologs and paralogs are two fundamentally different types of homologous genes that evolved, respectively, by vertical descent from a single ancestral gene and by duplication. Orthology and paralogy are key concepts of evolutionary genomics. A clear distinction between orthologs and paralogs is critical for the construction of a robust evolutionary classification of genes and reliable functional annotation of newly sequenced genomes. Genome comparisons show that orthologous relationships with genes from taxonomically distant species can be established for the majority of the genes from each sequenced genome. This review examines in depth the definitions and su...
Medical Subject Headings: animal structuresfungi
free text keywords: Genetics, Genomics, Biology, Conserved sequence, Gene duplication, OrthoDB, Inparanoid, Genome, Homology (biology), Evolutionary biology, Genetics, Gene
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