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</script>Progressive supranuclear palsy (PSP), previously known as Steele-Richardson-Olszweski syndrome, is an atypical parkinsonian syndrome with a prevalence of ∼5/100 000. It is an important differential diagnosis of more common idiopathic Parkinson's disease (iPD), where clinical differentiation is not straightforward and characteristic neuroimaging often yields a diagnostic clue. We describe a case of 75-year-old man with a history of slowness of activities and recurrent fall while walking, which was insidious in onset and gradually progressive for last 2 years. There was no history of tremor, stooping postures, urinary incontinence or hallucination. On examination supranuclear vertical gaze palsy with slow horizontal saccades, axial rigidity and bradykinesia were present. He had a slow gait with lack of associated movements and tendency to fall backwards. He had positive ‘dirty tie sign’ while eating. The patient was diagnosed as a probable case of PSP and MRI of the brain was done. Mid-sagittal T2-weighted MRI of the brain revealed characteristic selective atrophy of midbrain tegmentum (mesencephalon), with relatively preserved …
Male, Mesencephalon, Humans, Supranuclear Palsy, Progressive, Atrophy, Magnetic Resonance Imaging, Aged
Male, Mesencephalon, Humans, Supranuclear Palsy, Progressive, Atrophy, Magnetic Resonance Imaging, Aged
| citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 7 | |
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| influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Top 10% | |
| impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Average |
