publication . Article . 2012

Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial.

Jean-Yves Reginster; J. Badurski; Nicholas Bellamy; William G. Bensen; Roland Chapurlat; Xavier Chevalier; Claus Christiansen; Harry K. Genant; Federico Navarro; Nasonov El; ...
Open Access
  • Published: 01 Nov 2012
  • Publisher: eScholarship, University of California
Abstract
Objective. Background Strontium ranelate is currently used for osteoporosis. The international, double-blind, randomised, placebo-controlled Strontium ranelate Efficacy in Knee OsteoarthrItis triAl evaluated its effect on radiological progression of knee osteoarthritis.Methods. Patients with knee osteoarthritis (Kellgren and Lawrence grade 2 or 3, and joint space width (JSW) 2.5-5 mm) were randomly allocated to strontium ranelate 1 g/day (n=558), 2 g/day (n=566) or placebo (n=559). The primary endpoint was radiographical change in JSW (medial tibiofemoral compartment) over 3 years versus placebo. Secondary endpoints included radiological progression, Western Ont...
Subjects
Medical Subject Headings: musculoskeletal diseases
free text keywords: Humans, Osteoarthritis, Knee, Organometallic Compounds, Thiophenes, Antirheumatic Agents, Radiography, Treatment Outcome, Double-Blind Method, Aged, Middle Aged, Female, Male, Clinical Sciences, Immunology, Public Health and Health Services, Arthritis & Rheumatology, Clinical and Epidemiological Research, 1506, 1507, Knee Osteoarthritis, Osteoarthritis, Outcomes research, Immunology, General Biochemistry, Genetics and Molecular Biology, Immunology and Allergy, Rheumatology, Osteoporosis, medicine.disease, medicine, WOMAC, Knee pain, medicine.symptom, Strontium ranelate, medicine.drug, Osteoarthritis, Physical therapy, medicine.medical_specialty, business.industry, business, Placebo, Placebo-controlled study, Population, education.field_of_study, education, lcsh:Diseases of the musculoskeletal system, lcsh:RC925-935
40 references, page 1 of 3

1 Bijlsma JW Berenbaum F Lafeber FP Osteoarthritis: an update with relevance for clinical practice. Lancet 2011;377:2115–26 21684382 [OpenAIRE] [PubMed]

2 Cooper C Arden NK Excess mortality in osteoarthritis. BMJ 2011;342:d1407 21385808 [PubMed]

3 Zhang W Nuki G Moskowitz RW OARSI recommendations for the management of hip and knee osteoarthritis: part III: changes in evidence following systematic cumulative update of research published through January 2009. Osteoarthritis Cartilage 2010;18:476–99 20170770 [PubMed]

4 Tat SK Pelletier JP Mineau F Strontium ranelate inhibits key factors affecting bone remodelling in human osteoarthritic subchondral bone osteoblasts. Bone 2011;49:559–67 21700005 [PubMed]

5 Henrotin Y Labasse A Zheng SX Strontium ranelate increases cartilage matrix formation. J Bone Miner Res 2001;16:299–308 11204430 [OpenAIRE] [PubMed]

6 Gulhan I Bilgili S Gunaydin R The effect of strontium ranelate on serum insulin like growth factor-1 and leptin levels in osteoporotic post-menopausal women: a prospective study. Arch Gynecol Obstet 2008;278:437–41 18322691 [PubMed]

7 Bruyere O Delferriere D Roux C Effects of strontium ranelate on spinal osteoarthritis progression. Ann Rheum Dis 2008;67:335–9 17965119 [OpenAIRE] [PubMed]

8 Altman R Asch E Bloch D Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum 1986;29:1039–49 3741515 [PubMed]

9 Kellgren MJ The epidemiology of chronic rheumatism: atlas of standard radiographs. 2nd edn Oxford, UK: Blackwell Scientific, 1963

10 Cooper C Reginster J-Y Chapurlat R Efficacy and safety of oral strontium ranelate for the treatment of knee osteoarthritis: rationale and design of a randomised double-blind, placebo-controlled trial. Curr Med Res Opin 2012;28:231–9 22148897 [OpenAIRE] [PubMed]

11 Kothari M Guermazi A von Ingersleben G Fixed-flexion radiography of the knee provides reproducible joint space width measurements in osteoarthritis. Eur Radiol 2004;14:1568–73 15150666 [PubMed]

12 Gensburger D Roux JP Arlot M Influence of blinding sequence of radiographs on the reproducibility and sensitivity to change of joint space width measurement in knee osteoarthritis. Arthritis Care Res (Hoboken)2010;62:1699–705 20665746 [PubMed]

13 Botha-Scheepers S Watt I Breedveld FC Reading radiographs in pairs or in chronological order influences radiological progression in osteoarthritis. Rheumatology (Oxford)2005;44:1452–5 16091397 [PubMed]

14 Felson DT Nevitt MC Blinding images to sequence in osteoarthritis: evidence from other diseases. Osteoarthritis Cartilage 2009;17:281–3 18977156 [OpenAIRE] [PubMed]

15 Gensburger D Arlot M Sornay-Rendu E Radiologic assessment of age-related knee joint space changes in women: a 4-year longitudinal study. Arthritis Rheum 2009;61:336–43 19248124 [PubMed]

40 references, page 1 of 3
Abstract
Objective. Background Strontium ranelate is currently used for osteoporosis. The international, double-blind, randomised, placebo-controlled Strontium ranelate Efficacy in Knee OsteoarthrItis triAl evaluated its effect on radiological progression of knee osteoarthritis.Methods. Patients with knee osteoarthritis (Kellgren and Lawrence grade 2 or 3, and joint space width (JSW) 2.5-5 mm) were randomly allocated to strontium ranelate 1 g/day (n=558), 2 g/day (n=566) or placebo (n=559). The primary endpoint was radiographical change in JSW (medial tibiofemoral compartment) over 3 years versus placebo. Secondary endpoints included radiological progression, Western Ont...
Subjects
Medical Subject Headings: musculoskeletal diseases
free text keywords: Humans, Osteoarthritis, Knee, Organometallic Compounds, Thiophenes, Antirheumatic Agents, Radiography, Treatment Outcome, Double-Blind Method, Aged, Middle Aged, Female, Male, Clinical Sciences, Immunology, Public Health and Health Services, Arthritis & Rheumatology, Clinical and Epidemiological Research, 1506, 1507, Knee Osteoarthritis, Osteoarthritis, Outcomes research, Immunology, General Biochemistry, Genetics and Molecular Biology, Immunology and Allergy, Rheumatology, Osteoporosis, medicine.disease, medicine, WOMAC, Knee pain, medicine.symptom, Strontium ranelate, medicine.drug, Osteoarthritis, Physical therapy, medicine.medical_specialty, business.industry, business, Placebo, Placebo-controlled study, Population, education.field_of_study, education, lcsh:Diseases of the musculoskeletal system, lcsh:RC925-935
40 references, page 1 of 3

1 Bijlsma JW Berenbaum F Lafeber FP Osteoarthritis: an update with relevance for clinical practice. Lancet 2011;377:2115–26 21684382 [OpenAIRE] [PubMed]

2 Cooper C Arden NK Excess mortality in osteoarthritis. BMJ 2011;342:d1407 21385808 [PubMed]

3 Zhang W Nuki G Moskowitz RW OARSI recommendations for the management of hip and knee osteoarthritis: part III: changes in evidence following systematic cumulative update of research published through January 2009. Osteoarthritis Cartilage 2010;18:476–99 20170770 [PubMed]

4 Tat SK Pelletier JP Mineau F Strontium ranelate inhibits key factors affecting bone remodelling in human osteoarthritic subchondral bone osteoblasts. Bone 2011;49:559–67 21700005 [PubMed]

5 Henrotin Y Labasse A Zheng SX Strontium ranelate increases cartilage matrix formation. J Bone Miner Res 2001;16:299–308 11204430 [OpenAIRE] [PubMed]

6 Gulhan I Bilgili S Gunaydin R The effect of strontium ranelate on serum insulin like growth factor-1 and leptin levels in osteoporotic post-menopausal women: a prospective study. Arch Gynecol Obstet 2008;278:437–41 18322691 [PubMed]

7 Bruyere O Delferriere D Roux C Effects of strontium ranelate on spinal osteoarthritis progression. Ann Rheum Dis 2008;67:335–9 17965119 [OpenAIRE] [PubMed]

8 Altman R Asch E Bloch D Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum 1986;29:1039–49 3741515 [PubMed]

9 Kellgren MJ The epidemiology of chronic rheumatism: atlas of standard radiographs. 2nd edn Oxford, UK: Blackwell Scientific, 1963

10 Cooper C Reginster J-Y Chapurlat R Efficacy and safety of oral strontium ranelate for the treatment of knee osteoarthritis: rationale and design of a randomised double-blind, placebo-controlled trial. Curr Med Res Opin 2012;28:231–9 22148897 [OpenAIRE] [PubMed]

11 Kothari M Guermazi A von Ingersleben G Fixed-flexion radiography of the knee provides reproducible joint space width measurements in osteoarthritis. Eur Radiol 2004;14:1568–73 15150666 [PubMed]

12 Gensburger D Roux JP Arlot M Influence of blinding sequence of radiographs on the reproducibility and sensitivity to change of joint space width measurement in knee osteoarthritis. Arthritis Care Res (Hoboken)2010;62:1699–705 20665746 [PubMed]

13 Botha-Scheepers S Watt I Breedveld FC Reading radiographs in pairs or in chronological order influences radiological progression in osteoarthritis. Rheumatology (Oxford)2005;44:1452–5 16091397 [PubMed]

14 Felson DT Nevitt MC Blinding images to sequence in osteoarthritis: evidence from other diseases. Osteoarthritis Cartilage 2009;17:281–3 18977156 [OpenAIRE] [PubMed]

15 Gensburger D Arlot M Sornay-Rendu E Radiologic assessment of age-related knee joint space changes in women: a 4-year longitudinal study. Arthritis Rheum 2009;61:336–43 19248124 [PubMed]

40 references, page 1 of 3
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