Role of α-fetoprotein in differentiation of regulatory T lymphocytes
Copyright policy )Role of α-fetoprotein in differentiation of regulatory T lymphocytes
The effect of native α-fetoprotein (AFP) on the expression of T-regulatory lymphocyte (Treg) markers by activated CD4+ lymphocytes with different proliferative status was studied. α-Fetoprotein did not affect the ratio of proliferating and non-proliferating activated CD4+ cells. In the study of Treg differentiation, it was found that AFP at concentrations of 50 and 100 μg/mL significantly inhibited the number of nonproliferating CD4+FOXP3+ and CD4+FOXP3+HELIOS+ lymphocytes without affecting the expression of Treg markers by proliferating CD4+ lymphocytes.
- N. I. Lobachevsky State University of Nizhny Novgorod Russian Federation
- Institute of Ecology and Genetics of Microorganisms Russian Federation
- National Research Tomsk State University Russian Federation
- Department of Biological Sciences Russian Federation
- Russian Academy of Sciences Russian Federation
Adult, Humans, Cell Differentiation, Female, alpha-Fetoproteins, T-Lymphocytes, Regulatory, Cells, Cultured, Cell Proliferation
Adult, Humans, Cell Differentiation, Female, alpha-Fetoproteins, T-Lymphocytes, Regulatory, Cells, Cultured, Cell Proliferation
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