Inhibition of Streptococcus pneumoniae Penicillin-Binding Protein 2x and Actinomadura R39 DD-Peptidase Activities by Ceftaroline
Copyright policy )Inhibition of Streptococcus pneumoniae Penicillin-Binding Protein 2x and Actinomadura R39 DD-Peptidase Activities by Ceftaroline
ABSTRACT Although the rate of acylation of a penicillin-resistant form of Streptococcus pneumoniae penicillin-binding protein 2x (PBP2x) by ceftaroline is 80-fold lower than that of its penicillin-sensitive counterpart, it remains sufficiently high ( k 2 /K = 12,600 M −1 s −1 ) to explain the sensitivity of the penicillin-resistant strain to this new cephalosporin. Surprisingly, the Actinomadura R39 DD-peptidase is not very sensitive to ceftaroline.
570, MESH: Serine-Type D-Ala-D-Ala Carboxypeptidase, [SDV.BBM.BS] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], Acylation, Microbial Sensitivity Tests, Biochimie, biophysique & biologie moléculaire, Microbiology, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Species Specificity, Microbiologie, MESH: Anti-Bacterial Agents, Actinomycetales, Penicillin Binding Protein, MESH: Species Specificity, Penicillin-Binding Proteins, MESH: Acylation, MESH: Microbial Sensitivity Tests, MESH: Penicillin-Binding Proteins, MESH: Kinetics, Molecular Biology/Structural Biology [q-bio.BM], Life sciences, Serine-Type D-Ala-D-Ala Carboxypeptidase, Anti-Bacterial Agents, Cephalosporins, MESH: Actinomycetales, Kinetics, MESH: Cephalosporins, Streptococcus pneumoniae, Ceftaroline, Sciences du vivant, ceftaroline, MESH: Streptococcus pneumoniae, Biochemistry, biophysics & molecular biology
570, MESH: Serine-Type D-Ala-D-Ala Carboxypeptidase, [SDV.BBM.BS] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], Acylation, Microbial Sensitivity Tests, Biochimie, biophysique & biologie moléculaire, Microbiology, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Species Specificity, Microbiologie, MESH: Anti-Bacterial Agents, Actinomycetales, Penicillin Binding Protein, MESH: Species Specificity, Penicillin-Binding Proteins, MESH: Acylation, MESH: Microbial Sensitivity Tests, MESH: Penicillin-Binding Proteins, MESH: Kinetics, Molecular Biology/Structural Biology [q-bio.BM], Life sciences, Serine-Type D-Ala-D-Ala Carboxypeptidase, Anti-Bacterial Agents, Cephalosporins, MESH: Actinomycetales, Kinetics, MESH: Cephalosporins, Streptococcus pneumoniae, Ceftaroline, Sciences du vivant, ceftaroline, MESH: Streptococcus pneumoniae, Biochemistry, biophysics & molecular biology
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