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Publication . Article . 1988

The Human Immunodeficiency Virus: Infectivity and Mechanisms of Pathogenesis

Anthony S. Fauci;
Open Access
Published: 05 Feb 1988 Journal: Science, volume 239, pages 617-622 (issn: 0036-8075, eissn: 1095-9203, Copyright policy )
Publisher: American Association for the Advancement of Science (AAAS)
Abstract
Infection with the human immunodeficiency virus (HIV) results in a profound immunosuppression due predominantly to a selective depletion of helper/inducer T lymphocytes that express the receptor for the virus (the CD4 molecule). HIV also has tropism for the brain leading to neuropsychiatric abnormalities. Besides inducing cell death, HIV can interfere with T4 cell function by various mechanisms. The monocyte serves as a reservoir for HIV and is relatively refractory to its cytopathic effects. HIV can exist in a latent or chronic form which can be converted to a productive infection by a variety of inductive signals.
Subjects by Vocabulary

Microsoft Academic Graph classification: Biology Infectivity Immunology Viral disease Pathogenesis Immunosuppression medicine.medical_treatment medicine Tropism Virus Receptor Virology Monocyte medicine.anatomical_structure

Medical Subject Headings: virus diseases food and beverages

Subjects

Multidisciplinary

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