publication . Article . 1990

Molecular targets for AIDS therapy

Hiroaki Mitsuya; Robert Yarchoan; Samuel Broder;
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  • Published: 28 Sep 1990 Journal: Science, volume 249, pages 1,533-1,544 (issn: 0036-8075, eissn: 1095-9203, Copyright policy)
  • Publisher: American Association for the Advancement of Science (AAAS)
The development of antiretroviral therapy against acquired immunodeficiency syndrome (AIDS) has been an intense research effort since the discovery of the causative agent, human immunodeficiency virus (HIV). A large array of drugs and biologic substances can inhibit HIV replication in vitro. Nucleoside analogs--particularly those belonging to the dideoxynucleoside family--can inhibit reverse transcriptase after anabolic phosphorylation. 3'-Azido-2',3'-dideoxythymidine (AZT) was the first such drug tested in individuals with AIDS, and considerable knowledge of structure-activity relations has emerged for this class of drugs. However, virtually every step in the r...
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free text keywords: Multidisciplinary, Virology, Medicine, business.industry, business, Immunotherapy, medicine.medical_treatment, Immunopathology, Immunology, Viral disease, Acquired immunodeficiency syndrome (AIDS), medicine.disease, Reverse transcriptase, Dideoxynucleosides, Viral replication, Drug, media_common.quotation_subject, media_common
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Article . 1990
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