Sulfhydryl Compounds May Mediate Gastric Cytoprotection

descriptionPublicationkeyboard_double_arrow_right Article 09 Oct 1981 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 214, pages 200-202 (issn: 0036-8075, eissn: 1095-9203,

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Authors: S, Szabo; J S, Trier; P W, Frankel;

doi: 10.1126/science.7280691

pmid: 7280691

Sulfhydryl Compounds May Mediate Gastric Cytoprotection

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Abstract

Ethanol induces hemorrhagic gastric erosions and causes a dose-dependent decrease in the concentration of nonprotein sulfhydryl compounds in rat gastric mucosa. Sulfhydryl-containing drugs protect rats from ethanol-induced gastric erosions, whereas sulfhydryl blocking agents counteract the mucosal cytoprotective effect of prostaglandin F 2β . These observations suggest that endogenous nonprotein sulfhydryls may mediate prostaglandin-induced gastric cytoprotection and that sulfhydryl drugs may have potential for preventing or treating hemorrhagic gastric erosions.

Related Organizations

Brigham and Women's Faulkner Hospital
United States
Harvard University
United States

Keywords

Ethanol, Gastric Mucosa, Prostaglandins F, Sulfhydryl Reagents, Prostaglandins, Animals, Sulfhydryl Compounds, Rats

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