Human and Mouse Hypoxanthine-Guanine Phosphoribosyltransferase: Dimers and Tetramers

descriptionPublicationkeyboard_double_arrow_right Article 12 Jan 1979 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 203, pages 174-176 (issn: 0036-8075, eissn: 1095-9203,

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Authors: G G, Johnson; L R, Eisenberg; B R, Migeon;

doi: 10.1126/science.569362

pmid: 569362

Human and Mouse Hypoxanthine-Guanine Phosphoribosyltransferase: Dimers and Tetramers

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Abstract

Human and mouse hypoxanthine-guanine phosphoribosyltransferase subunits combine to form an active heteropolymer. Dimers form the basic subunit structure of the enzymes, yet the dimers can readily associate to form tetramers. The equilibrium between dimers and tetramers is significantly influenced by the ionic strength of the enzyme solvent.

Related Organizations

Johns Hopkins University School of Medicine
United States
Johns Hopkins Medicine
United States

Keywords

Hypoxanthine Phosphoribosyltransferase, X Chromosome, Genetic Linkage, Macromolecular Substances, Protein Conformation, Hybrid Cells, Cell Line, Molecular Weight, Mice, Animals, Humans, Female

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