
pmid: 14172601
The synthetic polynucleotides may be used as models for the effects of alkylating agents on nucleic acid. Alkylation of polyadenylic acid with methyl methanesulfonate yields a polymer methylated in the one-position of adenine. This alteration in structure produces marked changes in physical properties and decreases the capacity to code for polylysine synthesis.
Alkylating Agents, Chemistry, Alkylation, Chemical Phenomena, Nucleic Acids, Research, Spectrum Analysis, Polynucleotides, Proteins, Antineoplastic Agents, Peptides
Alkylating Agents, Chemistry, Alkylation, Chemical Phenomena, Nucleic Acids, Research, Spectrum Analysis, Polynucleotides, Proteins, Antineoplastic Agents, Peptides
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