Phosphorylation of Proteins by Inositol Pyrophosphates
Copyright policy )Phosphorylation of Proteins by Inositol Pyrophosphates
The inositol pyrophosphates IP 7 and IP 8 contain highly energetic pyrophosphate bonds. Although implicated in various biologic functions, their molecular sites of action have not been clarified. Using radiolabeled IP 7 , we detected phosphorylation of multiple eukaryotic proteins. We also observed phosphorylation of endogenous proteins by endogenous IP 7 in yeast. Phosphorylation by IP 7 is nonenzymatic and may represent a novel intracellular signaling mechanism.
- Johns Hopkins University School of Medicine United States
- Johns Hopkins University United States
- Johns Hopkins Medicine United States
Phosphotransferases (Phosphate Group Acceptor), Escherichia coli Proteins, Inositol Phosphates, Molecular Sequence Data, Nuclear Proteins, Proteins, Phosphates, Kinetics, Mice, Adenosine Triphosphate, Drosophila melanogaster, Amino Acid Substitution, Mutation, Animals, Drosophila Proteins, Humans, Magnesium, Amino Acid Sequence, Phosphorylation, Protein Kinases
Phosphotransferases (Phosphate Group Acceptor), Escherichia coli Proteins, Inositol Phosphates, Molecular Sequence Data, Nuclear Proteins, Proteins, Phosphates, Kinetics, Mice, Adenosine Triphosphate, Drosophila melanogaster, Amino Acid Substitution, Mutation, Animals, Drosophila Proteins, Humans, Magnesium, Amino Acid Sequence, Phosphorylation, Protein Kinases
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