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Characterization of a Novel Polymeric Trileaflet Heart Valve Prosthesis

Authors: Scott C. Corbett; Ahmet U. Coskun; Neil Verma; H. N. Hashemi; Parnian Boloori Zadeh;

Characterization of a Novel Polymeric Trileaflet Heart Valve Prosthesis

Abstract

While heart valve prostheses have been used successfully since 1960, 10-year survival rates still range from 37–58% [1]. The underlying problem with bioprostheses is a limited life from structural changes such as calcification and leaflet wear, leading to valve failure [2]. Biological tissue fixation and methods used to mount the tissue to a supporting stent can be blamed for this shortcoming. The underlying problem with mechanical heart valves is the presence of a centrally located leaflet, or occluder. It propagates high velocity jets, turbulence and areas of stagnation: the disturbances which necessitate anticoagulation [3]. A polyurethane valve has the potential to improve upon the shortcomings of existing valves and ultimately improve patient survival.

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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