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Publication . Article . 2010

Somatostatin and its receptors from fish to mammals: Gahete et al.

Gahete et al.
Manuel D. Gahete; Jose Cordoba-Chacon; Mario Durán-Prado; María M. Malagón; Antonio J. Martínez-Fuentes; Francisco Gracia-Navarro; Raúl M. Luque; +1 Authors
Open Access  
Published: 07 Jul 2010
Publisher: Zenodo
Somatostatin (SST) and its receptors (sst) make up a molecular family with unique functional complexity and versatility. Widespread distribution and frequent coexpression of sst subtypes underlies the multiplicity of (patho)physiological processes controlled by SST (central nervous system functions, endocrine and exocrine secretion, cell proliferation). This complexity is clearly reflected in the intricate evolutionary development of this molecular family. Recent studies postulate the existence of an ancestral somatostatin/urotensin II (SST/UII) gene, which originated two ancestral, SST and UII, genes by local duplication. Subsequently, segment duplication would have originated two diverging SST genes in both fish (SS1/SS2) and tetrapods [(SST/cortistatin(CST))]. SST/CST actions are mediated by a family of GPCRs (sst1-5) encoded by five different genes. sst1-4 sequences are highly conserved compared with sst5, suggesting unique evolutionary and functional relevance for the latter. Indeed, we recently identified novel truncated but functional sst5 variants in several species, which may help to explain part of the complexity of the SST/CST/sst family. Comparative and phylogenetic analysis of this molecular family would enhance our understanding of its paradigmatic evolutionary complexity and functional versatility.
Subjects by Vocabulary

Medical Subject Headings: endocrine system hormones, hormone substitutes, and hormone antagonists fluids and secretions fungi parasitic diseases

Microsoft Academic Graph classification: Endocrinology medicine.medical_specialty medicine Internal medicine Evolutionary biology Gene duplication Cortistatin (neuropeptide) Phylogenetic tree Biology Evolutionary developmental biology Somatostatin G protein-coupled receptor Gene Somatostatin receptor


History and Philosophy of Science, General Biochemistry, Genetics and Molecular Biology, General Neuroscience