publication . Article . 2012

Germinal center selection and the development of memory B and plasma cells

Mark J. Shlomchik; Florian Weisel;
Open Access
  • Published: 13 Apr 2012 Journal: Immunological Reviews, volume 247, pages 52-63 (issn: 0105-2896, Copyright policy)
  • Publisher: Wiley
Abstract
A hallmark of adaptive immune responses is the generation of long-lived protection after primary exposure to a pathogen. In humoral responses, this protection stems from a combination of sustained antibody titers and long-lived memory B cells (MBCs), with the former deriving from long-lived plasma cells (PCs). Both types of cell are thought to primarily derive from the germinal center (GC), a unique structure that forms during the immune response to many types of antigenic stimuli. GCs are seeded by antigen-specific B and T cells that were previously activated in the early stages of the response. The GC does not directly or immediately generate effector function...
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free text keywords: Immunology, Immunology and Allergy, Isotype, Cell biology, Antigen, Somatic hypermutation, Cell type, Germinal center, Immunology, Cell activation, Immune system, Biology, Cellular differentiation
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