Actions
  • shareshare
  • link
  • cite
  • add
add
auto_awesome_motion View all 11 versions
Publication . Article . 2018

Expression of the clock gene Rev-erbα in the brain controls the circadian organisation of food intake and locomotor activity, but not daily variations of energy metabolism

Satish Sen; Stéphanie Dumont; Dominique Sage-Ciocca; Sophie Reibel; P de Goede; Andries Kalsbeek; Etienne Challet;
Open Access
English
Published: 01 Jan 2018 Journal: Journal of neuroendocrinology, volume 30, issue 1 (issn: 0953-8194, Copyright policy )
Abstract
The nuclear receptor REV-ERBα is part of the molecular clock mechanism and thought to be involved in a variety of biological processes within metabolically active peripheral tissues as well. To investigate whether Rev-erbα (also known as Nr1d1) in the brain plays a role in the daily variations of energy metabolism, feeding behaviour and the sleep-wake cycle, we studied mice with global (GKO) or brain (BKO) deletion of Rev-erbα. Mice were studied both in a light-dark cycle and constant darkness, and 24-h variations of Respiratory quotient (RQ) and energy expenditure, as well as the temporal patterns of rest-activity and feeding behavior were recorded. The RQ increase of GKO mice was not detected in BKO animals, indicating a peripheral origin for this metabolic alteration. Arrhythmic patterns of locomotor activity were only found in BKO mice. By contrast, the circadian rhythm of food intake was lost both in GKO and BKO mice, mostly by increasing the number of daytime meals. These changes in the circadian pattern of feeding behaviour were, to some extent, correlated with a loss of rhythmicity of hypothalamic Hcrt (also named Orx) mRNA levels. Together, these findings highlight that Rev-erbα in the brain is involved in the temporal partitioning of feeding and sleep, whereas its effects on energy metabolism are mainly exerted through its peripheral expression. This article is protected by copyright. All rights reserved.
Subjects by Vocabulary

ACM Computing Classification System: ComputingMilieux_MISCELLANEOUS

Microsoft Academic Graph classification: Circadian rhythm Sleep in non-human animals Respiratory quotient Nuclear receptor Hypothalamus CLOCK Internal medicine medicine.medical_specialty medicine Peripheral Endocrinology Food intake Biology

Subjects

[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Journal Article, Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems, Endocrinology, Endocrinology, Diabetes and Metabolism

50 references, page 1 of 5

1. Golombek DA, Rosenstein RE. Physiology of circadian entrainment. Physiol Rev. 2010;90:1063-1102. [OpenAIRE]

2. Brown TM. Using light to tell the time of day: sensory coding in the mammalian circadian visual network. J Exp Biol. 2016;219: 1779-1792. [OpenAIRE]

3. Buijs RM, Kalsbeek A. Hypothalamic integration of central and peripheral clocks. Nat Rev Neurosci. 2001;2:521-526. [OpenAIRE]

4. Challet E. Keeping circadian time with hormones. Diabetes Obes Metab. 2015;17(suppl):176-183. [OpenAIRE]

5. Schibler U, Ripperger J, Brown SA. Peripheral circadian oscillators in mammals: time and food. J Biol Rhythms. 2003;18:250-260. [OpenAIRE]

6. Tahara Y, Shibata S. Chronobiology and nutrition. Neuroscience. 2013;253:78-88.

7. Ko CH, Takahashi JS. Molecular components of the mammalian circadian clock. Hum Mol Genet. 2006;15 Spec No 2:R271-R277.

8. Preitner N, Damiola F, Lopez-Molina L, et al. The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell. 2002;110:251-260. [OpenAIRE]

9. Guillaumond F, Dardente H, Giguere V, Cermakian N. Differential control of Bmal1 circadian transcription by REV-ERB and ROR nuclear receptors. J Biol Rhythms. 2005;20:391-403. [OpenAIRE]

10. Crumbley C, Burris TP. Direct regulation of CLOCK expression by REV-ERB. PLoS One. 2011;6:e17290. [OpenAIRE]

Funded by
WT
Project
  • Funder: Wellcome Trust (WT)
Related to Research communities
Download fromView all 6 sources
lock_open
moresidebar