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Publication . Article . 2018

Expression of the clock gene Rev-erbα in the brain controls the circadian organisation of food intake and locomotor activity, but not daily variations of energy metabolism

Satish Sen; Stéphanie Dumont; Dominique Sage-Ciocca; Sophie Reibel; P de Goede; Andries Kalsbeek; Etienne Challet;
Open Access
Published: 01 Jan 2018 Journal: Journal of neuroendocrinology, volume 30, issue 1 (issn: 0953-8194, Copyright policy )
The nuclear receptor REV-ERBα is part of the molecular clock mechanism and thought to be involved in a variety of biological processes within metabolically active peripheral tissues as well. To investigate whether Rev-erbα (also known as Nr1d1) in the brain plays a role in the daily variations of energy metabolism, feeding behaviour and the sleep-wake cycle, we studied mice with global (GKO) or brain (BKO) deletion of Rev-erbα. Mice were studied both in a light-dark cycle and constant darkness, and 24-h variations of Respiratory quotient (RQ) and energy expenditure, as well as the temporal patterns of rest-activity and feeding behavior were recorded. The RQ increase of GKO mice was not detected in BKO animals, indicating a peripheral origin for this metabolic alteration. Arrhythmic patterns of locomotor activity were only found in BKO mice. By contrast, the circadian rhythm of food intake was lost both in GKO and BKO mice, mostly by increasing the number of daytime meals. These changes in the circadian pattern of feeding behaviour were, to some extent, correlated with a loss of rhythmicity of hypothalamic Hcrt (also named Orx) mRNA levels. Together, these findings highlight that Rev-erbα in the brain is involved in the temporal partitioning of feeding and sleep, whereas its effects on energy metabolism are mainly exerted through its peripheral expression. This article is protected by copyright. All rights reserved.
Subjects by Vocabulary

ACM Computing Classification System: ComputingMilieux_MISCELLANEOUS

Microsoft Academic Graph classification: Circadian rhythm Sleep in non-human animals Respiratory quotient Nuclear receptor Hypothalamus CLOCK Internal medicine medicine.medical_specialty medicine Peripheral Endocrinology Food intake Biology


[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Journal Article, Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems, Endocrinology, Endocrinology, Diabetes and Metabolism

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  • Funder: Wellcome Trust (WT)
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