publication . Article . 2010

Intralesional bovine papillomavirus DNA loads reflect severity of equine sarcoid disease

Shelley Buchinger; V. Gerber; R. Haralambus; Ralf Steinborn; Joerg P Burgstaller; J. Klukowska-Rötzler; Sabine Brandt;
  • Published: 15 Apr 2010 Journal: Equine Veterinary Journal, volume 42, pages 327-331 (issn: 0425-1644, Copyright policy)
  • Publisher: Wiley
Summary Reasons for performing study: Sarcoids are nonmetastasising, yet locally aggressive skin tumours that constitute the most frequent neoplasm in equids. Infection by bovine papillomaviruses types 1 and 2 (BPV-1, BPV-2) has been recognised as major causative factor in sarcoid pathogenesis, but a possible correlation of intralesional virus load with disease severity has not been established thus far. Hypothesis: Given the pathogenic role of BPV-1 and BPV-2 in sarcoid disease, we suggest that intralesional viral DNA concentration may reflect the degree of affection. Methods: Severity of disease was addressed by recording the tumour growth kinetics, lesion num...
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Medical Subject Headings: viruses
free text keywords: Equine, General Medicine, Immunology, Bovine papillomavirus, biology.organism_classification, biology, Viral load, Real-time polymerase chain reaction, Lesion, medicine.symptom, medicine, Horse, Pathology, medicine.medical_specialty, Neoplasm, medicine.disease, Pathogenesis, Disease
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