Conformation of sturgeon pituitary somatotropin
Copyright policy )Conformation of sturgeon pituitary somatotropin
Pituitary somatotropin (growth hormone) from the sturgeon (Acipenser guldenstadti) has been studied by zero‐order and second‐order absorption spectroscopy, as well as by circular dichroism. Difference absorption spectra have also been generated during proteolytic digestion of the hormone. The molar extinction coefficient of the native protein was found to be 15 000 ± 110 M‐1 cm‐1 at 278.5 nm. Comparison of the conformations of sturgeon somatotropin and somatotropins isolated from several mammalian species, including bovine and human, indicates a close relationship between these molecules. Such similarities may be related to the relatively high biopotency of this fish hormone in mammalian assay systems.
- University of California, San Francisco United States
Protein Conformation, Growth Hormone, Fishes, Thermolysin, Animals, Spectrophotometry, Ultraviolet, Trypsin, Peptide Fragments
Protein Conformation, Growth Hormone, Fishes, Thermolysin, Animals, Spectrophotometry, Ultraviolet, Trypsin, Peptide Fragments
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