publication . Article . Other literature type . 2013

Epigenetic aspects of lymphocyte antigen receptor gene rearrangement or ‘when stochasticity completes randomness’

Sébastien Jaeger; Bastien Fernandez; Pierre Ferrier;
Open Access
  • Published: 01 Jun 2013 Journal: Immunology, volume 139, pages 141-150 (issn: 0019-2805, Copyright policy)
  • Publisher: Wiley
  • Country: France
Abstract
International audience; To perform their specific functional role, B and T lymphocytes, cells of the adaptive immune system of jawed vertebrates, need to express one (and, preferably, only one) form of antigen receptor, i.e. the immunoglobulin or T-cell receptor (TCR), respectively. This end goal depends initially on a series of DNA cis-rearrangement events between randomly chosen units from separate clusters of V, D (at some immunoglobulin and TCR loci) and J gene segments, a biomolecular process collectively referred to as V(D)J recombination. V(D)J recombination takes place in immature T and B cells and relies on the so-called RAG nuclease, a site-specific DN...
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free text keywords: Immunology, Immunology and Allergy, allelic exclusion, chromatin, epigenetics, immunoglobulin, T-cell receptor, V(D)J recombination, MESH: Animals, MESH: Epigenesis, Genetic/genetics, MESH: Humans, MESH: Models, Genetic, MESH: Models, Immunological, MESH: Receptors, Antigen, T-Cell/genetics, MESH: Receptors, Antigen, T-Cell/immunology, MESH: Stochastic Processes, MESH: T-Lymphocytes/immunology, MESH: T-Lymphocytes/metabolism, MESH: V(D)J Recombination/genetics, MESH: V(D)J Recombination/immunology, MESH: Epigenesis, Genetic/immunology, MESH: Gene Rearrangement, T-Lymphocyte/genetics, MESH: Gene Rearrangement, T-Lymphocyte/immunology, [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity, Review Articles, Recombinase, Biology, Allelic exclusion, Recombination-activating gene, T-cell receptor, V(D)J recombination, Acquired immune system, Genetics, Gene rearrangement, Epigenetics
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Other literature type . 2013
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