SummarySixteen cases of progressive systemic sclerosis (PSS) were studied in a large general hospital in Singapore from 1957 to 1967. Thirteen were Chinese and 3 Malays. The majority were middle‐aged housewives and half of the cases were seen less than six months after onset. A comparison of clinical features of this series and those from western countries was made. The pattern of cutaneous sclerosis was different and there was notable diminished incidence of Raynaud's phenomenon and associated secondary skin lesions. On the other hand, gastric and duodenal involvements seemed to be more common. A high percentage of cases had mild to moderate albuminuria without any other evidence of renal damage. The laboratory findings were similar to other western series, but with a low incidence of rheumatoid arthritis factor and antinuclear antibodies. Although steroids were given, the majority remained clinically unchanged. The prognosis for the chronic type of PSS is good.