
Background and purposeThe spectrum of COVID‐19, caused by severe acute respiratory syndrome coronavirus 2 infection (SARS‐CoV‐2), includes different neurologic manifestations of the central and peripheral nervous system.MethodsFrom March through April 2020, in two university hospitals located in western Switzerland, we examined three patients with Guillain–Barré syndrome (GBS) following SARS‐CoV‐2.ResultsThese cases were characterized by a primary demyelinating electrophysiological pattern (Acute inflammatory demyelinating polyneuropathy or AIDP) and a less severe disease course compared to recently published case series. Clinical improvement was observed in all patients at week five. One patient was discharged from hospital after full recovery with persistence of minor neurological signs (areflexia). Two of the three patients remained hospitalized: one was able to walk and the other could stand up with assistance.ConclusionsWe report three cases of typical GBS (AIDP) occurring after SARS‐CoV‐2 infection and presenting with a favourable clinical course. Given the interval between COVID‐19‐related symptoms and neurological manifestations (mean of 15 days) we postulate a secondary immune‐mediated mechanism rather than direct viral damage.
Immune-mediated disorder, Immunoglobulin therapy, 616.8, Polyradiculoneuropathy, Clinical Neurology, Neural Conduction, COVID-19, Immunoglobulins, Intravenous, COVID-19/complications; Disease Progression; Female; Guillain-Barre Syndrome/drug therapy; Guillain-Barre Syndrome/etiology; Guillain-Barre Syndrome/physiopathology; Humans; Immunoglobulins, Intravenous/therapeutic use; Middle Aged; Neural Conduction/physiology; Switzerland; Treatment Outcome; COVID-19; electrodiagnostic testing; immune-mediated disorder; immunoglobulin therapy; infection; polyradiculoneuropathy, Middle Aged, Guillain-Barre Syndrome, Electrodiagnostic testing, Treatment Outcome, 610/370, Neurology, 616, Disease Progression, Humans, Female, Infection, Switzerland
Immune-mediated disorder, Immunoglobulin therapy, 616.8, Polyradiculoneuropathy, Clinical Neurology, Neural Conduction, COVID-19, Immunoglobulins, Intravenous, COVID-19/complications; Disease Progression; Female; Guillain-Barre Syndrome/drug therapy; Guillain-Barre Syndrome/etiology; Guillain-Barre Syndrome/physiopathology; Humans; Immunoglobulins, Intravenous/therapeutic use; Middle Aged; Neural Conduction/physiology; Switzerland; Treatment Outcome; COVID-19; electrodiagnostic testing; immune-mediated disorder; immunoglobulin therapy; infection; polyradiculoneuropathy, Middle Aged, Guillain-Barre Syndrome, Electrodiagnostic testing, Treatment Outcome, 610/370, Neurology, 616, Disease Progression, Humans, Female, Infection, Switzerland
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