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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Contact Dermatitisarrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Contact Dermatitis
Article . 2016 . Peer-reviewed
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Occurrence and concentrations of isothiazolinones in detergents and cosmetics in Switzerland

Authors: Garcia-Hidalgo E; Sottas V; von Goetz N; Hauri U; Bogdal C; Hungerbühler K;

Occurrence and concentrations of isothiazolinones in detergents and cosmetics in Switzerland

Abstract

SummaryBackgroundIn recent years, the frequency of contact allergy to isothiazolinones has increased alarmingly in Europe, but only limited data are available on concentrations of isothiazolinones in consumer products.ObjectivesTo examine the current frequency of isothiazolinones [methylisothiazolinone (MI), methylchloroisothiazolinone (MCI), benzisothiazolinone (BIT), and octylisothiazolinone (OIT)] in a wide array of detergents and cosmetics relevant for the Swiss population.MethodsBy means of a market survey, the occurrence of isothiazolinones was investigated in 1948 consumer products. Of these, 88 products were analysed by liquid chromatography–high‐resolution mass spectrometry after ultrasonic extraction.ResultsOnly 7.6% of all cosmetics contained isothiazolinones, but the prevalence in detergents was much higher (42.9%). The measured concentration ranges in detergents were 4.3–10, 3.5–279, 3.8–186 and 7.9 ppm (one product only) for MI, MCI, BIT, and OIT, respectively. For cosmetics, these were 1.3–133 and 4.8 ppm (one product only) for MI and MCI, respectively.ConclusionsOur study has shown that high concentrations of isothiazolinones (including MI) can be found in a large variety of products, in particular in detergents. Therefore, the safe use of these preservatives should be re‐evaluated by including detergents in the exposure assessment.

Keywords

market survey, household cleaning products, personal care products, cosmetics, Detergents, Preservatives, Pharmaceutical, methylisothiazolinone, Cosmetics, biocides, Mass Spectrometry, methylchloroisothiazolinone, Thiazoles, benzisothiazolinone, Dermatitis, Allergic Contact, Humans, octylisothiazolinone, allergic contact dermatitis, Switzerland, Chromatography, Liquid

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
77
Top 1%
Top 10%
Top 10%
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