Topical ivermectin improves allergic skin inflammation
Copyright policy )Topical ivermectin improves allergic skin inflammation
AbstractBackgroundIvermectin (IVM) is widely used in both human and veterinary medicine to treat parasitic infections. Recent reports have suggested thatIVMcould also have anti‐inflammatory properties.MethodsHere, we investigated the activity ofIVMin a murine model of atopic dermatitis (AD) induced by repeated exposure to the allergenDermatophagoides farinae, and in standard cellular immunological assays.ResultsOur results show that topicalIVMimproved allergic skin inflammation by reducing the priming and activation of allergen‐specific T cells, as well as the production of inflammatory cytokines. WhileIVMhad no major impact on the functions of dendritic cellsin vivoandin vitro,IVMimpaired T‐cell activation, proliferation, and cytokine production following polyclonal and antigen‐specific stimulation.ConclusionAltogether, our results show thatIVMis endowed with topical anti‐inflammatory properties that could have important applications for the treatment of T‐cell‐mediated skin inflammatory diseases.
- French National Centre for Scientific Research France
- Ecole Normale Supérieure de Lyon France
- University of Montpellier France
- Nestlé Netherlands
- Jean Monnet University France
Enzyme-Linked Immunospot Assay, [SDV.IMM] Life Sciences [q-bio]/Immunology, Knockout, Administration, Topical, 610, Dermatitis, Lymphocyte Activation, Atopic, Cell Line, Dermatitis, Atopic, T-cell immunity, Fragile X Mental Retardation Protein, Mice, T-Lymphocyte Subsets, Receptors, Dermatophagoides, Animals, Humans, Antigens, Dermatophagoides, Antigens, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Mice, Knockout, Fragile X Messenger Ribonucleoprotein 1, Ivermectin, atopic dermatitis, Animal, Macrophages, 600, Dendritic Cells, Allergens, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, skin inflammatory diseases, Disease Models, Animal, topical treatment, Topical, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Administration, Disease Models, [SDV.IMM]Life Sciences [q-bio]/Immunology, Purinergic P2X4, Cytokines, [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Inflammation Mediators, Receptors, Purinergic P2X4
Enzyme-Linked Immunospot Assay, [SDV.IMM] Life Sciences [q-bio]/Immunology, Knockout, Administration, Topical, 610, Dermatitis, Lymphocyte Activation, Atopic, Cell Line, Dermatitis, Atopic, T-cell immunity, Fragile X Mental Retardation Protein, Mice, T-Lymphocyte Subsets, Receptors, Dermatophagoides, Animals, Humans, Antigens, Dermatophagoides, Antigens, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Mice, Knockout, Fragile X Messenger Ribonucleoprotein 1, Ivermectin, atopic dermatitis, Animal, Macrophages, 600, Dendritic Cells, Allergens, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, skin inflammatory diseases, Disease Models, Animal, topical treatment, Topical, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Administration, Disease Models, [SDV.IMM]Life Sciences [q-bio]/Immunology, Purinergic P2X4, Cytokines, [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Inflammation Mediators, Receptors, Purinergic P2X4
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