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Functionalized Mesoporous Silica Nanoparticles for Drug Delivery to Glioblastoma Multiforme

descriptionPublicationkeyboard_double_arrow_right Article , Conference object 04 Jul 2022Publisher:IEEEJournal:2022 IEEE 22nd International Conference on Nanotechnology (NANO)Funded by:EC | NANOFACTS

Authors: Nikola Knežević; Nebojša Ilić; Goran Kaluđerović;

doi: 10.1109/nano54668.2022.9928669

Functionalized Mesoporous Silica Nanoparticles for Drug Delivery to Glioblastoma Multiforme

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Abstract

Mesoporous silica nanoparticles (MSN) are covalently functionalized with Ir(III)-based complex and further characterized by nitrogen sorption, SEM, FTIR, EDS, TGA, DSC, DLS and zeta potential measurements. Controlled, pHresponsive delivery Ir(III)-complexes was noticed and demonstrated for efficient treatment of glioblastoma multiforme (GBM) cells upon exposure to acidification.

Related Organizations

Technical University of Munich
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Technical University of Munich (TUM)
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