Public Health Activity is an annual activity organized by the Public Health Center (Puskesmas) in every region in Indonesia. Puskesmas XYZ is a puskesmas located in an urban transition area with a large number of public health activities. In designing proposals and planning activities, Puskesmas XYZ does not yet have an integrated system between program executors and other fields. Data exchange, document archiving, and physical document flow are costly and time consuming without an integrated system. Designing an Enterprise Resource Planning system for the Puskesmas XYZ event management is the focus of the research that will be carried out. The OpenERP application with the Quickstart implementation method is considered appropriate because it has advantages and specifications that are suitable and in accordance with the puskesmas. The results of this study are related to the planning and implementation of Public Health Activities, integration of demand for goods to the warehouse, and integration into the health center website. This integration facilitates the flow of data in real time to program executors and other stakeholders. This system helps program implementation easily and data management to be integrated. With this system it also supports Puskesmas XYZ to become a smart puskesmas.