This chapter addresses the topic of ‘localisation policies’ (measures and incentives for attracting and developing companies) in relation to the actual subjects of such policies, their aims and targets. The existence of business relationships and networks, and the ubiquity of interaction processes make contemporary policy measures problematic in all these three aspects. Conceiving the business landscape as interactive and heterogeneous business networks leads the authors to argue that policy measures become ineffective when these neglect the networked nature of the business landscape. It is argued that localisation policies consist of multiple initiatives and involve ‘a network of policy actors’, rather than only one institution. Acknowledging the plurality of policy actors and means leads to focus on the need to orchestrate multifaceted localisation policies. Incentives, regulatory frameworks and public investments are some of the elements of the toolbox of localisation policy. The authors also argue that the business network perspective translates into the need to tailor policy measures differentiated for specific companies.